Magic 101 is a story of three sisters who live in a tropical post-apocalyptic island of Suspiria. The island is afflicted by a phenomenon known as the Fog. It either kills or turns anything it touches into monsters, pushing the sisters and any inhabitant of the island to endure living while avoiding it entirely. As the sisters continue their daily survival, they start attending the Suspiria's school of magic. However, they are unaware  of the dark secrets that the Fog hides, and specially of who's the mysterious figure that directs the school.