For thousands of years adolescents have been secretly abducted by entities from other worlds. The few that return have been shaken and irreparably altered by these events. A new international unit has been assembled to prevent further other world abductions, deal with those who have returned and perhaps one day, rescue those who have been taken. They are the Investigators of Supernatural Extradimensional Kidnapping of Adolescents Internationally. Also known, as I.S.E.K.A.I. Squad.